ALV-J strain SCAU-HN06 induces innate immune responses in chicken primary monocyte-derived macrophages

ALV-J strain SCAU-HN06 induces innate immune responses in chicken primary monocyte-derived macrophages

Avian leucosis virus subgroup J (ALV-J) can cause lifelong infection and can escape from the host immune defenses in chickens. Since macrophages act as the important defense line against invading pathogens in host innate immunity, we investigated the function and innate immune responses of chicken primary monocyte-derived macrophages (MDM) after ALV-J infection in this study. Our results indica...

Innate Immune Responses in ALV-J Infected Chicks and Chickens with Hemangioma In Vivo

Avian leukosis virus subgroup J (ALV-J) infection can cause tumors and immunosuppression. Since the precise mechanism of the innate immune response induced by ALV-J is unknown, we investigated the antiviral innate immune responses induced by ALV-J in chicks and chickens that had developed tumors. Spleen levels of interleukin-6 (IL-6), IL-10, IL-1β, and interferon-β (IFN-β) were not significantl...

Alum Induces Innate Immune Responses

ALV-J infection induces chicken monocyte death accompanied with the production of IL-1β and IL-18

Immunosuppression induced by avian leukosis virus subgroup J (ALV-J) causes serious reproduction problems and secondary infections in chickens. Given that monocytes are important precursors of immune cells including macrophages and dendritic cells, we investigated the fate of chicken monocytes after ALV-J infection. Our results indicated that most monocytes infected with ALV-J including field o...

Transcription Factor Stat3 Monocyte-Derived Macrophages via the IL-10 Induces IL-10 in Primary Human